study-shows-astrazeneca-vaccine-provides-‘minimal-protection’-against-south-africa-variant

Study shows AstraZeneca vaccine provides ‘minimal protection’ against South Africa variant

Science
26 min ago

Study shows AstraZeneca vaccine provides “minimal protection” against South Africa Covid-19 variant, Oxford University says 

From CNN’s Jamie Gumbrecht

Early data suggest two doses of the Oxford/AstraZeneca Covid-19 vaccine provide “minimal protection” against mild and moderate infection from the variant first identified in South Africa, the University of Oxford said Sunday. 

Viral neutralization against the B.1.351 variant was “substantially reduced” when compared to the earlier coronavirus strain, according to a news release Sunday from the University of Oxford. The study, which has not been released, included about 2,000 volunteers who were an average of 31 years old; about half received the vaccine and half received a placebo, which does nothing. The vaccine’s efficacy against severe Covid-19, hospitalization and death were not assessed.

Details of the study by researchers from South Africa’s University of Witwatersrand and others and the University of Oxford were shared in a press release. The results have been submitted for peer-review and a preprint will be released soon, Oxford said. 

After the study was reported Saturday by the Financial Times, AstraZeneca said in a statement it believes the vaccine could provide protection against severe disease, and said it has started to adapt the vaccine against the variant “so that it is ready for Autumn delivery should it be needed.”

“Efforts are underway to develop a new generation of vaccines that will allow protection to be redirected to emerging variants as booster jabs, if it turns out that it is necessary to do so,” Sarah Gilbert, a professor of vaccinology at the University of Oxford, said in Sunday’s statement, noting that this issue faces all vaccine developers. “We are working with AstraZeneca to optimise the pipeline required for a strain change should one become necessary.”

In the Oxford statement, Shabir Madhi, a professor of vaccinology at University of Witwatersrand who led the study, noted recent data in South Africa from Janssen, Johnson & Johnson’s vaccine arm, found some protection against moderate and severe Covid-19 disease with a similar vaccine. 

“These findings recalibrate thinking about how to approach the pandemic virus and shift the focus from the goal of herd immunity against transmission to the protection of all at risk individuals in population against severe disease,” Madhi said. 

52 min ago

San Francisco public schools and unions reach tentative agreement on school reopening, unions say

From CNN’s Gisela Crespo

The unions representing workers at the San Francisco Unified School District announced they have reached a tentative agreement with the school district to reopen schools for in-person learning amid the Covid-19 pandemic.

In a news release Sunday, the unions said the tentative agreement “outlines the baseline health and safety standards and vaccine access to physically reopen public schools.”

The agreement would allow teachers and workers to return to school in the red tier of California’s reopening criteria if Covid-19 vaccines are made available, according to the release. Return to in-person instruction can happen without vaccine availability in the orange tier. 

The district would also provide personal protective equipment for students and staff, socially distanced classrooms and workspaces, and regular testing, among other safety protocols.

“This is a major step forward toward a goal that we share with so many parents: safe reopening of school buildings for students and staff,” the unions say in the release.

San Francisco filed a lawsuit against its own school district Wednesday to get schools to physically open, CNN previously reported.

CNN has reached out to San Francisco Unified School District and the Mayor’s Office for comment.

59 min ago

Major snowstorm forces Netherlands to close Covid-19 vaccination centers

From CNN’s Martin Goillandeau

The Dutch regional health agencies (GGD) said they closed all Covid-19 test sites and vaccination locations on Sunday, after the country’s national meteorological institute (KNMI) declared a rare “Code Red” warning for the whole territory.

“If you have an appointment for a test or vaccination on Sunday, do not come to the location,” a statement from GGD read, adding that 20,000 people with a testing appointment and 20,000 others with a vaccination appointment would be informed by telephone about the situation.

Called “Storm Darcy” by Dutch media, the first major snowstorm to hit the country in 10 years has disrupted rail and road traffic, according to reports from the country’s Directorate-General for Public Works and Water Management. National train operator NS said in a statement that no trains would run on Sunday due to “adverse weather conditions.”

56 min ago

Democrats will introduce $3,000 per child benefit Monday as part of stimulus package

From CNN’s Daniella Diaz and Tami Luhby

Rep. Richard Neal speaks at a press conference in Washington, DC, on July 24, 2020. Michael Brochstein/Sipa

House Democratic leaders will unveil legislation Monday that would give families at least $3,000 per child, advancing a key provision in President Joe Biden’s $1.9 trillion Covid-19 relief package.

Chairman of the Ways and Means Committee Rep. Richard Neal is leading the crafting of the legislation for the stimulus package and will introduce the enhanced Child Tax Credit bill tomorrow, according to a House Ways and Means Committee spokesperson.

“The pandemic is driving families deeper and deeper into poverty, and it’s devastating. We are making the Child Tax Credit more generous, more accessible, and by paying it out monthly, this money is going to be the difference in a roof over someone’s head or food on their table,” Neal said in a statement provided to CNN.

The 22-page legislation would provide $3,600 per child under the age of six and $3,000 per child age six through 17 for a single year. The size of the benefit would phase out for single Americans earning more than $75,000 per year, as well as for couples jointly earning more than $150,000 per year.

Families would also be able to receive the Child Tax Credit payments on a monthly basis.

If this particular legislation is passed by Congress, the payments would begin in July for one year.

Reps. Rosa DeLauro, Suzan DelBene and Ritchie Torres are also set to introduce standalone legislation on Monday, known as the American Family Act, that would continue the benefit permanently.

Rep. DeLauro, who has been working on expanding the child tax credit since 2003, said in a statement to CNN:

“We cannot stop here. We must use this moment to pass the American Family Act and permanently expand and improve the child tax credit. One year is not enough for the children and families battling not just the coronavirus, but poverty, too.”

The Washington Post was the first to report details of the legislation and the fact that it would be unveiled Monday.

1 hr 7 min ago

WHO Panel will meet Monday to discuss AstraZeneca Covid-19 vaccine

From CNN’s Naomi Thomas

Vials of the AstraZeneca Covid-19 vaccine in London on January 7. Leon Neal/Getty Images

The World Health Organization’s independent panel on vaccinations will meet on Monday to discuss the AstraZeneca vaccine and studies assessing how effective it is against the virus variant first identified in South Africa, Maria Van Kerkhove, WHO’s technical lead for Covid-19, said on CBS’s Face the Nation Sunday. 

A spokesperson for AstraZeneca told CNN on Saturday that a small trial found the company’s Covid-19 vaccine provides limited protection against mild disease in cases caused by the B.1.351 variant. The study has not yet been peer-reviewed or published.

When asked if she was concerned about AstraZeneca’s vaccine and the variant, Van Kerkhove told CBS’s Margaret Brennan that there were a number of studies underway to look at immune responses. 

There are “some preliminary studies suggesting reduced efficacy. But again, those studies aren’t fully published yet,” Van Kerkhove said.

“Our independent panel group on vaccinations is meeting tomorrow to specifically discuss the AstraZeneca vaccine as well as the results coming out of South Africa to determine what does this mean in terms of the vaccines going forward,” Van Kerkhove said. 

She added that it’s critical to have more than one safe and effective vaccine: “We cannot rely on only one product.”

1 hr 52 min ago

76 health care workers are going to the Super Bowl on the New England Patriots’ plane

From CNN’s Elizabeth Joseph

The Patriots posted this photo on Sunday morning of the 76 Super Bowl-bound vaccinated health care workers. From New England Patriots/Twitter

76 vaccinated health care workers from New England are traveling to Super Bowl LV in Tampa, Florida, on the Patriots team plane today.

Massachusetts Gov. Charlie Baker, New England Patriots President Jonathan Kraft and New England Patriots Captain Matthew Slater participated in the sendoff Sunday morning.

“I’m thrilled to be back here today because today the Kraft family and the Patriots and the NFL are saying thank you to so many of our health care workers who have carried a tremendous burden of serving and taking care of and saving the lives of so many people during this pandemic,” Baker said.

He continued: “And honestly when you think about some of those great Patriots slogans, “Do your job,” “no days off,” there’s probably no group over the course of this pandemic who’s demonstrated that more day after day after day than our health care workers, and I’m thrilled to be here today, to be able to say thank you to all of them for what they’ve done and who they’ve represented, and how they’ve represented the Commonwealth, here in Massachusetts and taken care of so many people who struggle with COVID and their families.”

2 hr 26 min ago

WHO official praises UK’s approach of spacing out second vaccines doses 

From CNN’s Arnaud Siad

The British approach on having a bigger gap between the first and second Covid-19 vaccine dose has been “vindicated,” World Health Organization Special Envoy David Nabarro said on Sunday.

Speaking on Sky News, Nabarro said:

“I think the UK’s approach, so far at least, has been vindicated. And yes, I think this is a great lesson for the rest of the world. Thank you, thank you British scientists.” 

“Isn’t it wonderful that it has turned out that, as a result of the UK’s bravery, frankly, that this extended interval seems to be associated with even greater protection? That’s how we’re doing Covid at the moment, we’re all learning together, different countries approaching it in different ways,” he added.  

The UK currently prioritizes the first dose of a vaccine, with a second dose up to 12 weeks later, a bigger gap than originally planned. 

Nabarro explained that the WHO’s advice on intervals between vaccine doses has been “based on what the manufacturers did during the what we call Phase 3 trials of the vaccine. Then the WHO and its committees really has to work on the basis of what manufacturers told them.”

“That committee is meeting pretty often at the moment because there’s a lot of vaccines coming onstream, and the committee has to look at vaccines and it will indeed look again at the doses as a result of the British experience,” he added.

The WHO currently recommends second doses of the Pfizer-BioNTech and Moderna vaccines should be delivered up to 4 weeks after the first, and up to six weeks later in “exceptional circumstances.” It is currently in the process of evaluating the Oxford-AstraZeneca vaccine for emergency use.

However, speaking earlier on NBC’s Meet the Press, Dr. Anthony Fauci, director of the US National Institute of Allergy and Infectious Diseases, said there may not be enough time to study the efficacy of receiving one vaccine dose and people should stick to the available data. 

Fauci said: “From a theoretical standpoint, it would be nice to know if you just get one dose, how long the durability lasts and what is the level of effect… But, what we have right now and what we must go with is the scientific data that we’ve accumulated and it’s really very solid.” 

The current data Fauci was referring to says people should get a booster dose 21 days after their first Pfizer shot and 28 days after the first Moderna shot. 

1 hr 43 min ago

Covid-19 vaccine demand is greater than current supply, Dr. Fauci says 

From CNN’s Naomi Thomas

Drivers wait in line at a Covid-19 vaccination site in the parking lot of Dodger Stadium in Los Angeles on January 27. Damian Dovarganes/AP

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, told NBC’s Meet the Press Sunday that the number of vaccines doses available is improving, but demand was always going to going to be greater than the early supply.

“The demand clearly outstrips the supply right now,” Fauci said when asked what’s holding up US vaccine supply. “If you look at the escalation of availability of doses purely on the ability and the capability of manufacturing that, it’s going to escalate and will continue to escalate as we go from February to March to April and beyond.” 

He said that even though there’s a “clear, clear discrepancy” between the demand and the supply, it will get better as the year progresses.

“But that is the limiting factor, Chuck,” Fauci said. “It’s the supply/demand issue.” 

Manufacturing began even before vaccines were authorized for use, but health officials warned for months that not everyone would be able to get vaccinated immediately. 

When Todd asked if the US should have expanded manufacturing months ago, Fauci said this situation was a bit inevitable. 

“We certainly, I guess, could have contracted a little bit more aggressively with the companies to get more doses,” he said. “But right now, this is what we have, these are the contractual arrangements, they’re coming off the line as quickly as we can.” 

In addition to more doses of the Moderna and Pfizer vaccines coming available, Fauci said, the Johnson & Johnson vaccine may be available soon. The company submitted to the US Food and Drug Administration for emergency use authorization for the vaccine y last week .

1 hr 48 min ago

There may not be enough time to study the efficacy of receiving one Covid vaccine dose, Dr. Fauci says

From CNN’s Naomi Thomas

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, listens during a news conference at the White House on January 21. Al Drago/Bloomberg/Getty Images

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said there may not be enough time to study the efficacy of receiving one vaccine dose and people should stick to the available data. 

Some experts have supported the idea of delaying second doses of Covid-19 vaccines in order to get as many people as possible vaccinated with at least a first dose.  

Speaking to NBC’s Chuck Todd Sunday, Fauci said: “From a theoretical standpoint, it would be nice to know if you just get one dose, how long the durability lasts and what is the level of effect… But, what we have right now and what we must go with is the scientific data that we’ve accumulated and it’s really very solid.” 

The current data say people should get a booster dose 21 days after their first Pfizer shot and 28 days after the first Moderna shot. 

“You can do both. You can get as many people in their first dose, at the same time as adhering within reason to the timetable of the second dose,” Fauci said. “So it would be great to have the study, but I don’t think we could do it in time.”